Dementia risk 🦠

"We identified 260 out of 942 immunologically relevant proteins in plasma that were differentially expressed in individuals with an infection history. 

"Of the infection-related proteins, 35 predicted volumetric changes in brain regions vulnerable to infection-specific atrophy. Several of these proteins, including PIK3CG, PACSIN2, and PRKCB, were related to cognitive decline and plasma biomarkers of dementia (Aβ42/40, GFAP, NfL, pTau-181). 

"Genetic variants that influenced expression of immunologically relevant infection-related proteins, including ITGB6 and TLR5, predicted brain volume loss. 

"Our findings support the role of infections in dementia risk and identify molecular mediators by which infections may contribute to neurodegeneration."




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