Development of spoken language

"NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival in mice and normal development in humans. 

"A single amino acid change (I197V) in NOVA1’s second RNA binding domain is unique to modern humans. 

"To study its physiological effects, we generated mice carrying the human-specific I197V variant (Nova1hu/hu) and analyzed the molecular and behavioral consequences. While the I197V substitution had minimal impact on NOVA1’s RNA binding capacity, it led to specific effects on alternative splicing, and CLIP revealed multiple binding peaks in mouse brain transcripts involved in vocalization. 

"These molecular findings were associated with behavioral differences in vocalization patterns in Nova1hu/hu mice as pups and adults. 

Comments

Post a Comment

Empathy recommended

Popular posts from this blog

Hamza Chaudhry

"Although a nuclear confrontation based on fake intelligence may seem unlikely, the stakes during crises are high and timelines are short, creating situations where fake data could well tilt the balance toward nuclear war. "The evolution of nuclear systems has led to further ambiguity in crises and shorter timeframes for verifying intelligence. An intercontinental ballistic missile from Russia could reach the U.S. within 25 minutes. A submarine-launched ballistic missile could arrive even sooner.  "Many modern missiles carry ambiguous payloads, making it unclear whether they are nuclear-tipped. AI tools for verifying the authenticity of content are not sufficiently reliable, making this ambiguity difficult to resolve in a short window. "The likeliest nuclear hotspots are also the arenas involving actors with low levels of trust on both sides — be that the U.S. and the Chinese Communist Party or Russia, or India and Pakistan. Even if communication is established in a...
Read more

Swarm 🦹‍♂️

"Knowledge discovery from data typically includes solving some type of an optimization problem that can be efficiently addressed using algorithms belonging to the class of evolutionary and bio-inspired computation .  "In this chapter, we give an overview of the various kinds of evolutionary algorithms, such as genetic algorithms, evolutionary strategy, evolutionary and genetic programming, differential evolution, and coevolutionary algorithms, as well as several other bio-inspired approaches, like swarm intelligence and artificial immune systems.  "After elaborating on the methodology, we provide numerous examples of applications in astronomy and geoscience and show how these algorithms can be applied within a distributed environment, by making use of parallel computing, which is essential when dealing with Big Data."
Read more

Digital ID tracking system

The U.S. Transportation Security Administration (TSA) has moved forward with regulations establishing a smartphone-based national digital ID and tracking system, disregarding objections from organizations like the Identity Project. These new rules are based on the REAL-ID Act of 2005 and set the standards for how states will issue digital versions of driver’s licenses or ID cards, which will be accepted by the TSA and other federal agencies for certain official purposes. However, these rules do not extend to airline travel, where no ID is legally required, despite the TSA’s misleading statements to the contrary. Under the TSA’s new regulations, digital IDs can only be issued to individuals who already possess a physical driver’s license or state-issued ID card. Additionally, individuals are still obligated by state laws to carry their physical ID while driving, even if they have a digital ID on their smartphone.  This shift is not primarily about improving driver’s license technolo...
Read more