Gene expression + mitochondria


"For example, in fruit flies, defects in metabolic enzymes in a subset of tissues can trigger a stress response that halts the growth and development of the entire animal. 

"By genetically blocking the stress response, the researchers reversed the effect.

"Most recently, in February 2025 in Science, the endocrinologist Scott Soleimanpour at the University of Michigan found that in mice with defective mitochondria, beta cells (special cells that produce insulin) were de-differentiating —losing their identity as beta cells and reverting to a more immature state. 

"By inhibiting the stress response, his team could get the beta cells to re-differentiate, much as Chandel could restore the lung cells in his mice if he suppressed their stress response."


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